Daniela Delneri

About

Daniela is currently a Full Professor at the University of Manchester in the area of Evolutionary and Functional Genomics and became Associate Dean for Research and Innovation in Biology/Biotech in November 2023. In previous years she was the Research Director of the “Computational and Evolutionary Biology” Group in the Faculty of Life Sciences at the University of Manchester (2013-2016). As undergraduate, she studied Biological Sciences and graduated with 110/110 cum Laude (1991) from the University of Trieste, Italy, with a thesis in the field of infection and medical microbiology. She was awarded the PhD in Biochemistry in 1997 (University of Trieste & ICGEB, Area Science Park, Trieste), where she focussed on biodegradation pathways of lignocellulose derivatives in bacteria and yeast. She was able to secure an EC TMR Senior Fellow at UMIST (1997-1999) studying the importance of genetic redundancy on evolutionary processes. She started her independent career in 2004 as NERC Advanced Fellow at the University of Manchester, UK. With twenty-five years’ worth of experience in yeast genetics and molecular biology, she focusses on understanding the interplay between genes and environment, including plasticity of mutations in protein coding genes and non-coding RNAs elements, the impact of chromosomal rearrangements on reproductive isolation and fitness, and the evolution of genomes in hybrid species including biotechnological aspects. She collaborates with several industries in strain development via hybridisation and trait selection in particularly relevant to the food and beverage sector and to the biorefinery processes.

Work

The University of Manchester

United Kingdom of Great Britain and Northern Ireland

University of Manchester

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Professor of Evolutionary Genomics

United Kingdom of Great Britain and Northern Ireland

Education

University of Trieste

Italy
PhD Biochemistry

University of Trieste

Italy
Laurea in Biologia (BSc Honour Biological Sciences)

Publications

Silica hydrogels as a carbon-free solid media for the culture of diverse organisms

FEMS microbes

journal-article

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

Nature Communications

journal-article

Effect of Hanseniaspora vineae and Saccharomyces cerevisiae co-fermentations on aroma compound production in beer.

Food microbiology

journal-article

Development of a genome-scale metabolic model for the lager hybrid yeast S. pastorianus to understand the evolution of metabolic pathways in industrial settings

mSystems

journal-article

Development of a genome-scale metabolic model for the lager hybrid yeast S. pastorianus to understand the evolution of metabolic pathways in industrial settings.

mSystems

journal-article

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.

Nature communications

journal-article

Minimisation of metabolic networks defines a new functional class of genes.

Nature communications

journal-article

High quality de novo genome assembly of the non-conventional yeast Kazachstania bulderi describes a potential low pH production host for biorefineries.

Communications biology

journal-article

High quality de novo genome assembly of the non-conventional yeast Kazachstania bulderi describes a potential low pH production host for biorefineries

Communications Biology

journal-article

Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target

Research Square

journal-article

Development of a genome scale metabolic model for the lager hybrid yeastS. pastorianusto understand evolution of metabolic pathways in industrial settings

working-paper

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus.

Nature communications

journal-article

Mitonuclear interplay in yeast: from speciation to phenotypic adaptation.

Current opinion in genetics & development

journal-article

Eisosome disruption by noncoding RNA deletion increases protein secretion in yeast.

PNAS nexus

journal-article

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus

Nature Communications

journal-article

Quantitative Characterisation of Low Abundant Yeast Mitochondrial Proteins Reveals Compensation for Haplo-Insufficiency in Different Environments

International Journal of Molecular Sciences

journal-article

Volatile aroma compound production is affected by growth rate in S. cerevisiae

Applied and Environmental Microbiology|A E M

journal-article

Volatile Aroma Compound Production Is Affected by Growth Rate in S. cerevisiae.

Applied and environmental microbiology

journal-article

Eisosome disruption by non-coding RNA deletion increases protein secretion in yeast

PNAS Nexus

journal-article

Transcriptional Profile of the Industrial Hybrid Saccharomyces pastorianus Reveals Temperature-Dependent Allele Expression Bias and Preferential Orthologous Protein Assemblies

Molecular Biology and Evolution

journal-article

Restoring fertility in yeast hybrids: Breeding and quantitative genetics of beneficial traits

Proceedings of the National Academy of Sciences

journal-article

Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory network

PLoS Genetics

journal-article

Genomic Adaptation of Saccharomyces Species to Industrial Environments

Frontiers in Genetics

journal-article

HybridMine

Microorganisms

journal-article

HybridMine: A Pipeline for Allele Inheritance and Gene Copy Number Prediction in Hybrid Genomes and Its Application to Industrial Yeasts

Microorganisms

journal-article

An update on the diversity, ecology and biogeography of the Saccharomyces genus

FEMS Yeast Research

journal-article

Plasticity of Mitochondrial DNA Inheritance and its Impact on Nuclear Gene Transcription in Yeast Hybrids

Microorganisms

journal-article

Plasticity of Mitochondrial DNA Inheritance and Its Impact on Nuclear Gene Transcription in Yeast Hybrids

Microorganisms

journal-article

High throughput gene replacement in Aspergillus fumigatus

Current Protocols in Microbiology

journal-article

Fast and reliable PCR amplification from Aspergillus fumigatus spore suspension without traditional DNA extraction

Current Protocols in Microbiology

journal-article

Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments

Environmental Microbiology Reports

journal-article

Large-scale profiling of noncoding RNA function in yeast

PL o S Genetics

journal-article

HISTORY OF GENOME EDITING IN YEAST

Yeast

journal-article

Whole genome sequencing, de novo assembly and phenotypic profiling for the new budding yeast species Saccharomyces jurei

G3: Genes, Genomes, Genetics (Bethesda)

journal-article

A resource for functional profiling of noncoding RNA in the yeast Saccharomyces cerevisiae

RNA

journal-article

Rapid functional and evolutionary changes follow gene duplication in yeast

Proceedings of the Royal Society B: Biological Sciences

journal-article

Saccharomyces jureii sp. nov., Isolation and Genetic Identification of a Novel Yeast Species from Quercus robur.

International Journal of Systematic and Evolutionary Microbiology

journal-article

Novel Intronic RNA Structures Contribute to Maintenance of Phenotype in Saccharomyces cerevisiae

Genetics

journal-article

Induced expression of defence-related genes in barley is specific to aphid genotype

Biological Journal of the Linnean Society

journal-article

Induced expression of defence‐related genes in barley is specific to aphid genotype

other

Widespread Impact of Chromosomal Inversions on Gene Expression Uncovers Robustness via Phenotypic Buffering.

journal-article

Widespread Impact of Chromosomal Inversions on Gene Expression Uncovers Robustness via Phenotypic Buffering

Molecular Biology and Evolution

journal-article

Non-coding RNAs and disease: the classical ncRNAs make a comeback

Biochemical Society Transactions

journal-article

Non-coding RNAs and disease: the classical ncRNAs make a comeback.

journal-article

Novel Intronic RNA Structures Contribute to Maintenance of Phenotype in Saccharomyces cerevisiae.

journal-article

Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse

PLoS ONE

journal-article

Osteoblastic cell secretome: a novel role for progranulin during risedronate treatment.

journal-article

Limb Displays of Male Saitis barbipes (Simon, 1868) (Araneae: Salticidae)

Arachnology

journal-article

Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures

Molecular ecology

journal-article

Intron evolution in Saccharomycetaceae

Genome biology and evolution

journal-article

Intron evolution in Saccharomycetaceae.

journal-article

Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures.

journal-article

Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse.

journal-article

Chimeric Protein Complexes in Hybrid Species Generate Novel Phenotypes

PL o S Genetics

journal-article

Chimeric protein complexes in hybrid species generate novel phenotypes.

journal-article

Characterization and prediction of haploinsufficiency using systems-level gene properties in yeast.

journal-article

Osteoblastic cell secretome: A novel role for progranulin during risedronate treatment.

Bone

journal-article

Characterization and prediction of haploinsufficiency using systems-level gene properties in yeast

G3: Genes, Genomes, Genetics

journal-article

Non-coding RNAs in Saccharomyces cerevisiae: what is the function?

journal-article

Impact of chromosomal inversions on the yeast DAL cluster

PLoS ONE

journal-article

Impact of chromosomal inversions on the yeast DAL cluster.

journal-article

Non-coding RNAs in Saccharomyces cerevisiae: What is the function?

Biochemical Society Transactions

journal-article

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability.

Environmental microbiology

journal-article

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability.

journal-article

The yeast factory.

journal-article

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

Molecular Biology of the Cell

journal-article

Competition experiments coupled with high-throughput analyses for functional genomics studies in yeast

Yeast Systems Biology

book-chapter

Competition experiments coupled with high-throughput analyses for functional genomics studies in yeast.

journal-article

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.

journal-article

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness

Molecular Biology of the Cell

journal-article

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness.

journal-article

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body

Molecular Biology of the Cell

journal-article

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.

journal-article

Correction: Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast.

journal-article

Evolutionary systems biology of amino acid biosynthetic cost in yeast

PLoS ONE

journal-article

Gene duplication and environmental adaptation within yeast populations.

journal-article

Gene duplication and environmental adaptation within yeast populations

Genome biology and evolution

journal-article

Evolutionary systems biology of amino acid biosynthetic cost in yeast.

journal-article

Barcode technology in yeast: Application to pharmacogenomics

FEMS Yeast Research

journal-article

Barcode technology in yeast: application to pharmacogenomics.

journal-article

New generation of loxP-mutated deletion cassettes for the genetic manipulation of yeast natural isolates

Yeast

journal-article

New generation of loxP-mutated deletion cassettes for the genetic manipulation of yeast natural isolates.

journal-article

Genome-Wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

Proteomics

journal-article

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection

Genome biology

journal-article

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.

journal-article

Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates

Journal of Proteome Research

journal-article

Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates.

journal-article

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

journal-article

Probing (macro)molecular transport through cell walls

Faraday Discussions

journal-article

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures

Nature Genetics

journal-article

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures.

journal-article

Probing (macro)molecular transport through cell walls.

journal-article

Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan.

journal-article

Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity

Genome biology

journal-article

Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity.

journal-article

Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan

Eukaryotic Cell

journal-article

Plasticity of genetic interactions in metabolic networks of yeast

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Plasticity of genetic interactions in metabolic networks of yeast.

journal-article

Development of novel guanidino-labelling derivatisation (GLaD) reagents for liquid chromatography/matrix-assisted laser desorption/ionisation analysis

Rapid communications in mass spectrometry : RCM

journal-article

Development of novel guanidino-labelling derivatisation (GLaD) reagents for liquid chromatography/matrix-assisted laser desorption/ionisation analysis.

journal-article

Functional Analysis, Genome Redundancy and Speciation in Yeast

book

Effects of reciprocal chromosomal translocations on the fitness of Saccharomyces cerevisiae

EMBO reports

journal-article

Effects of reciprocal chromosomal translocations on the fitness of Saccharomyces cerevisiae.

journal-article

The use of yeast mutant collections in genome profiling and large-scale functional analysis

Current Genomics

journal-article

GIMS: an integrated data storage and analysis environment for genomic and functional data.

journal-article

GIMS: An integrated data storage and analysis environment for genomic and functional data

Yeast

journal-article

Engineering evolution to study speciation in yeasts

Nature

journal-article

Engineering evolution to study speciation in yeasts.

journal-article

Tools for the study of genome rearrangements in laboratory and industrial yeast strains

Yeast

journal-article

Tools for the study of genome rearrangements in laboratory and industrial yeast strains.

journal-article

Towards a truly integrative biology through the functional genomics of yeast

Current Opinion in Biotechnology

journal-article

Towards a truly integrative biology through the functional genomics of yeast.

journal-article

Exploring redundancy in the yeast genome: An improved strategy for use of the cre-loxP system

Gene

journal-article

Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system.

journal-article

Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real

Genetics

journal-article

Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real.

journal-article

Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain

Yeast

journal-article

Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain.

journal-article

Characterization of microbial cellulose from a high-producing mutagenized Acetobacter pasteurianus strain

Biochimica et Biophysica Acta - General Subjects

journal-article

Characterization of microbial cellulose from a high-producing mutagenized Acetobacter pasteurianus strain.

journal-article

The nucleotide sequence of Saccharomyces cerevisiae chromosome VII

Nature

journal-article

The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.

journal-article

Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae

Yeast

journal-article

Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae.

journal-article

Degradation of trans-ferulic and p-coumaric acid by Acinetobacter calcoaceticus DSM 586

Biochimica et Biophysica Acta - General Subjects

journal-article

Degradation of trans-ferulic and p-coumaric acid by Acinetobacter calcoaceticus DSM 586.

journal-article

Immunodominant antigens recognized by the human immune response to infection by organisms of the species Leptospira interrogans serogroup Australis.

journal-article

Immunodominant antigens recognized by the human immune response to infection by organisms of the species Leptospira interrogans serogroup Australis

FEMS microbiology letters

journal-article

Daniela Delneri